Distinctive Uptake of Neutral Red by Mitotic Cancer Cells
作者:
SitK. H.,
BayB. H.,
WongK. P.,
期刊:
Biotechnic&Histochemistry
(Taylor Available online 1992)
卷期:
Volume 67,
issue 4
页码: 196-201
ISSN:1052-0295
年代: 1992
DOI:10.3109/10520299209110066
出版商: Taylor&Francis
关键词: A431;malignant melanoma;oral carcinoma;hepatoma;Chang liver cells;epidermal growth factor;nuclear influx
数据来源: Taylor
摘要:
Neutral red stains both normal and cancer mitotic cells, but uptake by living mitotic cancer cells is distinctly higher than in normal cells. This new approach to cancer cell identification is demonstrated in 4 established tumorigenic cancer cell lines: human skin epidermoid carcinoma A431, mouse Cloudman malignant melanoma, human oral epidermoid carcinoma and rat hepatoma. Human Chang liver cells served as normal controls. With epidermal growth factor (EGF) prepulse, neutral red uptake is dramatically enhanced. The possibility of a causal relationship with M-phase specific phosphorylation is discussed.
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