A randomized comparative study: Amorolfine (cream 0.125%, 0.25% and 0.5%) in dermatomy coses
作者:
del PalacioA.,
LópezS.,
GimenoC.,
GarciaC.,
CuetaraS.,
GarciaM.,
IglesiasL.,
期刊:
Journal of Dermatological Treatment
(Taylor Available online 1991)
卷期:
Volume 1,
issue 6
页码: 299-303
ISSN:0954-6634
年代: 1991
DOI:10.3109/09546639109086762
出版商: Taylor&Francis
数据来源: Taylor
摘要:
In a double-blind randomized comparative study, 75 patients with dermatomycoses (one cutaneous candidosis and 74 dermatophyte infections) were treated with amorolfine cream 0.125% (group A, 25 patients), 0.25% (group B, 25 patients) or 0.5% (group C, 25 patients). Treatment, consisting of a once daily application, was continued for 1 week after clinical cure, the maximum duration of treatment was limited to 6 weeks. Assessment of the results was based on both clinical and mycological parameters. At the end of the treatment clinical cure rates ranged from 76% to 84%, and mykological cure ranged from 64% to 76%. There were two patients in each group (8%) who did not respond to the treatment, and eight patients had to withdraw due to side-effects. At the assessment 2 months post-therapy 20 patients (80%) in group A, 17 (68%) in group B and 18 (72%) in group C were cured. There were six relapses: 3 (12%) in group B and 3 (12%) in group C. There was no significant difference between the three groups in terms of clinical and mycological response, duration of treatment or tolerance.
点击下载:
PDF (477KB)
返 回