Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids
作者:
M.A. Lea,
G. Weber,
H.P. Morris,
期刊:
Oncology
(Karger Available online 1976)
卷期:
Volume 33,
issue 5-6
页码: 205-208
ISSN:0030-2414
年代: 1976
DOI:10.1159/000225145
出版商: S. Karger AG
关键词: Glycolysis;Free fatty acids;Hepatomas;Renal tumor
数据来源: Karger
摘要:
The action of free fatty acids on glycolytic enzymes was compared in normal and neoplastic tissues. Preincubation of tissue supernatant fractions with octanoate or laurate caused an inhibition of the activities of hexokinase and phosphofructokinase. An inhibition was also observed of lactate production with either glucose or glucose 6-phosphate as substrate. A similar degree of inhibition was observed for actions on normal liver and kidney, on the 7800 and 3924-A hepatomas and on the MK-3 renal cortical tumor. The possible relationship between the inhibition of glycolytic enzymes by fatty acids and anti-tumor activity previously observed with these compounds was noted.
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