SCHNEIDER, D. A., G. H. KAMIMORI, S. Y. WU, M. T. MCENIERY, and C. SOLOMON. Plasma catecholamine and ventilatory responses to cycling after propranolol treatment.Med. Sci. Sports Exerc., Vol. 27, No. 12, pp. 1616–1620, 1995. The purpose of the present study was to examine the relationship between minute ventilation (&OV0312;E) and plasma concentrations of epinephrine (EPI) and norepinephrine (NE) during incremental cycling (20 W·2 min-1) performed under conditions of β-adrenergic blockade (80 mg of propranolol) and placebo in six untrained male subjects. No significant differences existed between treatments in O2uptake, CO2output, blood lactate, pH, or &OV0312;Eduring the submaximal work stages of incremental exercise common to both treatments (20–220 W). During exercise with β-blockade, EPI, and NE concentrations were both significantly elevated compared with control levels at every submaximal work stage. Significant positive correlations between &OV0312;Eand plasma levels of EPI and NE were found during both β-blockade (r = 0.98 and 1.00) and control conditions (r = 0.98 and 0.96). Although the high correlations were unchanged during exercise with β-blockade, the slopes of the regression lines for the &OV0312;E-EPI and the &OV0312;E-NE relationships were both significantly reduced compared with control conditions, β-blockade resulted in elevated plasma levels of both EPI and NE compared with control conditions without causing a change in exercise &OV0312;E. These findings suggest that catecholamines may not be important substances in regulating breathing during exercise.