DIRECT SEPARATION OF LABETALOL STEREOISOMERS IN A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY SYSTEM USING HELICALLY SELF-ASSEMBLED CHELATE AS CHIRAL SELECTOR IN THE MOBILE PHASE1†
作者:
Grzegorz Bazylak,
HassanY. Aboul-Enein,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1999)
卷期:
Volume 22,
issue 8
页码: 1171-1192
ISSN:1082-6076
年代: 1999
DOI:10.1081/JLC-100101725
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Efficiency of transient supramolecular enantioselective recognition processes during direct, isocratic RP-HPLC separation of all four stereoisomers (SR,RS,SSandRR) of labetalol, chemically known as 2-hydroxy-5-[1-hydroxy-2-((1-methyl-3-phenylpropyl) amino)ethyl] benzamide, an antihypertensive agent with combined alpha- and beta-adrenoceptor blocking activities, have been presented. In the developed RP-HPLC system the conventional octadecylsilica packed column and double-helical chelate (-)(M)(λ,Λ)-[4,4'-(1S)-methyl-(2R)-propylethane-diyldi-imino) bis(pent-3-en-2-onato)]nickel(II) as the chiral mobile phase additive was used.
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