Hyperalgesia and allodynia induced by intrathecal (RS)‐dihydroxyphenylglycine in rats
作者:
Kim Fisher,
Terence Coderre,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 6
页码: 1169-1172
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Allodynia;Dihydroxyphenylglycine;DHPG;Hyperalgesia;Metabotropic glutamate receptors;mGluR;Nociception
数据来源: OVID
摘要:
To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR1/5agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48°C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses to a tail pinch. These data suggest that activation of spinal mGluR1/5receptors plays a role in the development of persistent allodynia and hyperalgesia associated with tissue or nerve injury.
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