Inhibition of adherence and cytotoxicity by circulating immune complexes formed in experimental filariasis
作者:
LINDA M. KARAVODIN,
L. R. ASH,
期刊:
Parasite Immunology
(WILEY Available online 1982)
卷期:
Volume 4,
issue 1
页码: 1-12
ISSN:0141-9838
年代: 1982
DOI:10.1111/j.1365-3024.1982.tb00415.x
出版商: Blackwell Publishing Ltd
关键词: Brugia pahangi;circulating immune complexes;PEC adherence;antibody‐dependent cytotoxicity
数据来源: WILEY
摘要:
SummaryPeritoneal exudate cells (PEC) from normal jirds (Meriones unguiculatus) showed adherence toBrugia pahangimicrofilariae, and subsequent cytotoxicity in the presence of antimicrofilarial antisera. Heat inactiviation of the antisera diminished both adherence and cytotoxicity, but readdition of fresh normal jird sera only partially restored the reactions. Macrophages were the predominant adherent cell type. Circulating immune complexes precipitated with polyethylene glycol (PEG) from the sera of jirds with an 8‐month infection inhibited both of these reactions. Complement consumption by the precipitated complexes was found not to be the cause of inhibition. Blocking of adherence and cytotoxicity by circulating immune complexes may be preventing the trapping of microfilariaein vivo, and may play a role in the persistence of microfilaraemia in the jir
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