Diastolic Function of the Heart in Untreated Primary Hypertension
作者:
MARIANNE HARTFORD,
JOHN WIKSTRAND,
INGEMAR WALLENTIN,
SUSANNE LJUNGMAN,
LARS WILHELMSEN,
GORAN BERGLUND,
期刊:
Hypertension
(OVID Available online 1984)
卷期:
Volume 6,
issue 3
页码: 329-338
ISSN:0194-911X
年代: 1984
出版商: OVID
关键词: primary hypertension;left ventricular relaxation time;wall thickness;structural vascular changes
数据来源: OVID
摘要:
To study left ventricular (LV) diastolic function of the heart in relation to blood pressure (BP) and other signs of hypertensive cardiac and peripheral vascular changes, isovolumic relaxation time and early diastolic filling were determined in four BP groups of untreated 49-year-old men: normotensive subjects (n = 20), men with borderline hypertension (n = 30), mild hypertension (n = 45), and moderate to severe hypertension (n = 24). Isovolumic relaxation time, measured as the distance between aortic closure (A2, phonocardiography) and mitral valve opening (echocardiography), and early diastolic filling, measured as the distance between mitral valve opening and the O point of the apexcardiogram, tended to increase with BP level, and the total interval from aortic closure to the O point (A2O interval) was significantly prolonged in the two groups with mild and moderate to severe hypertension. A prolonged A2O interval (⩾117% of expected value at observed heart rate) was seen in several hypertensives, who had no obvious increase in LV wall thickness on M mode echocardiography. This suggests that a prolonged LV relaxation time may be an early sign of cardiac involvement in primary hypertension. In the group with moderate to severe hypertension, an increase in LV wall thickness was seen together with an increase in resistance at maximal dilation in the calf. This supports the theory that when changes in cardiac structure develop they occur in parallel with structural changes also in the periphery.
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