Inhibitory Effect of Caerulein on Salivary Secretion in Man
作者:
C. Loguercio,
D. Costato,
C. Del Vecchio Blanco,
期刊:
Digestion
(Karger Available online 1991)
卷期:
Volume 48,
issue 3
页码: 128-133
ISSN:0012-2823
年代: 1991
DOI:10.1159/000200684
出版商: S. Karger AG
关键词: Caerulein;Pentagastrin;Salivary secretion
数据来源: Karger
摘要:
Previous works have documented that pentagastrin has a stimulatory effect on salivary secretion. In this paper, we have studied the action of caerulein, a peptide that has an active gastrin-like terminal tetrapeptide, on salivary secretion in man. Our data documented that caerulein and pentagastrin have a similar excitatory effect on gastric secretion in man, but different actions on salivary flow. Caerulein, at increasing doses, inhibits salivary flow, but not the secretion of amylase; this effect is statistically significant at 0.5 µg/kg/h which is the same dose that maximally stimulates gastric secretion. The inhibitory effect of caerulein was not reversed by previous injection of papavarin
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