Vacuolar H+-ATPase: functional mechanisms and potential as a target for cancer chemotherapy
作者:
Takayuki Torigoe,
Hiroto Izumi,
Tomoko Ise,
Tadashi Murakami,
Hidetaka Uramoto,
Hiroshi Ishiguchi,
Yoichiro Yoshida,
Mizuho Tanabe,
Minoru Nomoto,
Kimitoshi Kohno,
期刊:
Anti-Cancer Drugs
(OVID Available online 2002)
卷期:
Volume 13,
issue 3
页码: 237-243
ISSN:0959-4973
年代: 2002
出版商: OVID
关键词: Cancer;chemosensitivity;pH regulation;vacuolar H+-ATPase
数据来源: OVID
摘要:
Tumor cellsin vivooften exist in a hypoxic microenvironment with a lower extracellular pH than that surrounding normal cells. Ability to upregulate proton extrusion may be important for tumor cell survival. Such microenvironmental factors may be involved in the development of resistant subpopulations of tumor cells. In solid tumors, both intracellular and extracellular pH differ between drug-sensitive and -resistant cells, and pH appears critical to the therapeutic effectiveness of anticancer agents. Four major types of pH regulators have been identified in tumor cells: the sodium–proton antiporter, the bicarbonate transporter, the proton–lactate symporter and proton pumps. Understanding mechanisms regulating tumor acidity opens up novel opportunities for cancer chemotherapy. In this minireview, we describe the structure and function of certain proton pumps overexpressed in many tumors—vacuolar H+-ATPases—and consider their potential as targets for cancer chemotherapy.
点击下载:
PDF
(232KB)
返 回