Risk factors of gastric precancerous lesions in a high‐risk Colombian population. II. nitrate and nitrite
作者:
ChenVivienW.,
Abu‐ElyazeedRemonR.,
ZavalaDiegoE.,
HaenszelWilliam,
KtsanesVirginiaK.,
RiceJanet,
CuelloCarlos,
MontesGuillermo,
CorreaPelayo,
期刊:
Nutrition and Cancer
(Taylor Available online 1990)
卷期:
Volume 13,
issue 1-2
页码: 67-72
ISSN:0163-5581
年代: 1990
DOI:10.1080/01635589009514046
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractGastric nitrite content was studied in relation to precancerous lesions of the stomach in a case‐control study conducted in a high‐risk Colombian population. The proportion of detectable nitrite in gastric juice and the mean pH were significantly higher among those with precancerous lesions (chronic atrophic gastritis, intestinal metaplasia, and dysplasia) than among the controls (normal and superficial gastritis); the proportion and mean pH increased with the progression of histological changes from normal to dysplasia. Nitrite was not detectable in gastric juice with a pH less than 5.0. A positive association was found between the proportion of detectable nitrite and the risk of gastric precancerous lesions. Odds ratios of 4.39 for intestinal metaplasia and 24.72 for dysplasia remained significant after controlling for confounders. This finding suggests that nitrite may be a precursor of a mutagen that targets gastric epithelial cells.
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