Tubular Toxicity Is the Main Renal Effect of Contrast Media
作者:
DonadioCarlo,
TramontiGianfranco,
LucchesiAnnalisa,
GiordaniRoberto,
LucchettiAmalia,
BianchiClaudio,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 4
页码: 647-656
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609047690
出版商: Taylor&Francis
关键词: Nephrotoxicity;Contrast media;Glomerular function;Tubular function;Urinary enzymes;Alanine aminopeptidase;γ-Glutamyltransferase;Alkaline phosphatase;Lactate dehydrogenase;AT-Acetyl-β-D-glucosaminidase;Lysozyme;Glomerular filtration rate
数据来源: Taylor
摘要:
The aim of this study is to evaluate the effects of contrast media on both tubular and glomerular function. Different parameters of tubular and glomerular function were determined before and at 1, 3, and 5 days after the intravascular administration of contrast media in 100 adult renal patients (plasma creatinine 0.6-10.8 mg/dL, mean: 1.3). Urinary activities of five tubular enzymes (alanine aminopeptidase,γ-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase, N-acetyl-β-D-glucosaminidase) increased significantly on the first day after the administration of contrast media, indicating a tubular damage. Glomerular filtration rate and the conventional tests of glomerular function (plasma creatinine, creatinine clearance, and urinary proteins) presented only slight variations after the administration of contrast media. In conclusion, contrast media principally affected the renal tubule (as demonstrated by enzymuria), while their effects on glomerular function were very mild.
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