Enteric Cryptosporidiosis in Pediatric HIV Infection
作者:
Guarino Alfredo,
Castaldo Annunziata,
Russo Stefania,
Spagnuolo Maria,
Canani Roberto,
Tarallo Luigi,
DiBenedetto Linda,
Rubino Armido,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 1997)
卷期:
Volume 25,
issue 2
页码: 182-187
ISSN:0277-2116
年代: 1997
出版商: OVID
关键词: Cryptosporidiosis;Cryptosporidium;Diarrhea;HIV;Malabsorption
数据来源: OVID
摘要:
BackgroundEnteric cryptosporidiosis is a frequent problem in adults with human immunodeficiency virus (HIV) infection, but little is known of its features in children. The aim of this study was to investigate the incidence and the clinical features of cryptosporidiosis in HIV-infected children.MethodsThirty-five children with symptomatic HIV infection were screened every 2 months, and in case of diarrhea, for the presence ofCryptosporidium. Intestinal function tests were performed, and the fecal osmotic gap was measured in children with cryptosporidiosis.ResultsSeventy episodes of diarrhea occurred in 16 children in a median period of 17 months.Cryptosporidiumwas detected in five cases, all with full-blown acquired immunodeficiency syndrome. Cryptosporidiosis was significantly more protracted than any other form of diarrhea and was associated with dehydration and severe weight loss. Intestinal function was not modified during cryptosporidiosis. Osmotic gap values were consistent with secretory rather than osmotic diarrhea. In four cases, recovery was observed without specific treatment.ConclusionsEnteric cryptosporidiosis is a severe problem in advanced stages of HIV infection. It does not induce intestinal malabsorption. It induces diarrhea of secretory type. Recovery may be observed independently of therapy.
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