EFFECTS OF GLUCAGON ON PANCREATIC SECRETION IN THE DOG
作者:
K. Iwatsuki,
H. Ono,
K. Hashimoto,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1976)
卷期:
Volume 3,
issue 1
页码: 59-65
ISSN:0305-1870
年代: 1976
DOI:10.1111/j.1440-1681.1976.tb00591.x
出版商: Blackwell Publishing Ltd
关键词: glucagon;pancreatic secretion;pancreozymin;secretin.
数据来源: WILEY
摘要:
SUMMARY1. The effects of glucagon on the secretion of pancreatic juice were investigated using blood‐perfused canine pancreas preparations.2. Intravenous administration of glucagon (3–30 μg/kg) to the donor dog elicited a dose‐dependent increase in pancreatic secretion. Intra‐arterial administration of glucagon (10–100 μg) into the perfused pancreas also elicited increased secretion.3. There were slight increases in amylase concentration of the pancreatic juice with the largest doses of glucagon given by either route.4. Glucagon‐induced secretion was not modified by treatment with phentolamine, propranolol, atropine, guanethidine, tetrodotoxin, haloperidol, prostaglandin F2a or calcitonin.5. The results suggest that glucagon acts directly on the exocrine cells of the ca
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