Effects of Dichloroacetate on Pyruvate Metabolism in Rat Brain inVivo
作者:
YASUHIRO KURODA,
KENJI TOSHIMA,
TOSHIYUKI WATANABE,
HIDEAKI KOBASHI,
MICHINORI ITO,
EIJI TAKEDA,
MASUHIDE MIYAO,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 10
页码: 936-938
ISSN:0031-3998
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
SummaryThe effects of dichloroacetate (DCA) on the activity of the pyruvate dehydrogenase (PDH) complex and associated changes in the lactate and glucose levels in rat brain were investigatedin vivo.The average activities of the active form of the PDH complex in the brain, liver and muscle of starved rats were respectively 0.40 ± 0.04, 0.07 ± 0.04, and 0.17 ± 0.11 &mgr;mol/min/g tissue, and amounted to 21, 11, and 16% of the total activity of the complex. Intraperitoneal injection of DCA (125 mg/kg) increased the percentage of the active form of the PDH complex in the brain, liver, and muscle to 107, 40, and 84%, respectively. DCA significantly lowered the lactate and glucose concentrations of the brain and blood. A lower dose of DCA (12.5 mg/kg) also caused significant increase in activity of the PDH complex in the brain, but did not significantly change the lactate or glucose concentration of the brain. These results suggest that DCA crosses the blood‐brain barrier reasonably well.AbbreviationsPDH, pyruvate dehydrogenaseDCA, dichloroacetate
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