Effects of subchronic parathion administration on sodium salicylate excretion kinetics in female rats
作者:
Laura Martínez Tabche,
Francisco A. Posadas Del Rio,
期刊:
Journal of Applied Toxicology
(WILEY Available online 1989)
卷期:
Volume 9,
issue 1
页码: 5-8
ISSN:0260-437X
年代: 1989
DOI:10.1002/jat.2550090103
出版商: John Wiley&Sons, Ltd.
关键词: gentisic acid;LD50;organophosphates;salicylates;salicyluric acid;xenobiotic interaction
数据来源: WILEY
摘要:
AbstractOrganophosphorus (OP) pesticides are considered to be environmental contaminants, and chronic exposure to low levels through the diet may affect drug action. To study this possible interaction, ethyl parathion was administered by intubation to female rats for 35 consecutive days at a dose of 0.05 or 0.2 mg/kg of body weight per day. At 7, 21 and 35 days after parathion was initiated, rats were administered a single dose of 20 mg/kg sodium salicylate intraperitoneally. Total salicylates, salicyclic acid (SA), salicyluric acid (SU) and gentisic acid (GA) were determined in urine. At 7 days, parathion treatment slowed the excretion of total salicylates. This effect was more evident at longer treatment times. Total excretion of SA was increased at the expense of GA at 7 days. However, this effect was reversed at 21 and 35 days. Excretion of SU was drastically diminished after 21 days of treatment with parathion. The results suggest that subchronic oral administration of parathion to female rats changes the excretion kinetics of sodium salicylate through combined effects on renal excretion mechanisms and biotransformation processes. Thus, exposure to low concentrations of environmental contaminants may produce important changes in drug action.
点击下载:
PDF
(394KB)
返 回