MOLECULAR AND CELLULAR RESPONSES OF THE CORNEAL EPITHELIUM TO WOUND HEALING
作者:
Roger W. Beuerman,
Hilary W. Thompson,
期刊:
Acta Ophthalmologica
(WILEY Available online 1992)
卷期:
Volume 70,
issue S202
页码: 7-12
ISSN:1755-375X
年代: 1992
DOI:10.1111/j.1755-3768.1992.tb02161.x
出版商: Blackwell Publishing Ltd
关键词: c‐fos;cornea;epidermal growth factor;gene expression;wound healing
数据来源: WILEY
摘要:
AbstractThe corneal epithelium responds rapidly to injury, repairing defects with a layer of cells that covers the denuded corneal surface and prevents infection and loss of vision. After a wound, reorganization of the remaining epithelial cells occurs over several hours, resulting in the formation of a migratory leading edge. However, expression of genes such as c‐fosoccurs within minutes of wounding. This early expression may be important for directing epithelial reorganization and the later mitotic burst. Our results show that receptors for epidermal growth factor are upregulated in the migratory cell population. Proliferation through a mitotic burst was observed in cells surrounding the original wound margin after 36 hours. The interaction between gene expression and cell surface receptors for growth factors and cell proliferation suggests that wound healing occurs in a complex, but tightly controlled process in the corneal epitheliu
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