Influence of Azathioprine on the Ferrokinetics of Patients with Renal Failure before and after Treatment with Erythropoietin
作者:
E. Anastassiades,
D. Howarth,
J.E. Howarth,
D. Shanks,
H.M. Waters,
K. Hyde,
J.A. Liu Yin,
C.G. Geary,
R. Gokal,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 3
页码: 291-296
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187981
出版商: S. Karger AG
关键词: Renal anaemia;Azathioprine;Erythropoietin;Ferrokinetics;Ineffective erythropoiesis
数据来源: Karger
摘要:
In 16 patients (9 on azathioprine, 7 not) the ineffective iron turnover (I IT) was much higher in the azathioprine group (62.7 ± 6.7 vs. 23.5 ± 3.5 μmol/l blood/ day, p < 0.0001, 2-tailed t test), though the red cell iron turnover (ROT) was similar (42.8 ± 2.9 vs. 41 ± 4.8). Erythropoietin improved the anaemia in all patients and raised the RCIT (4 still on azathioprine to 72.2 ± 9.8, p < 0.003; 7 non-azathioprine patients to 62.7 ± 5.3, p < 0.01); the ΠT remained higher in the azathioprine-treated (85.5 ± 19.3 vs. 37.1 ± 5.4; p < 0.013). In 2 patients who discontinued azathioprine, the IIT declined markedly to normal. In summary, azathioprine exacerbates the anaemia of renal failure by augmenting ineffective erythropoiesis, while erythropoietin benefits those on azathioprine as much as other renal patients by stimulating both effective and ineffective eryth
点击下载:
PDF
(1204KB)
返 回