Glycogenosis Type V (McArdle’s Disease) with Hyperuricemia
作者:
K. Jinnai,
N. Kono,
Y. Yamamoto,
F. Kanda,
S. Ohno,
M. Tsutsumi,
Y. Yamada,
M. Kawachi,
S. Tarui,
T. Fujita,
期刊:
European Neurology
(Karger Available online 1993)
卷期:
Volume 33,
issue 3
页码: 204-207
ISSN:0014-3022
年代: 1993
DOI:10.1159/000116937
出版商: S. Karger AG
关键词: Glycogenosis type V;McArdle’s disease;Hyperuricemia;Purine metabolite;Fructose
数据来源: Karger
摘要:
A 28-year-old male with glycogenosis type V associated with continuous hyperuricemia during mild daily activities is reported. An aerobic exercise test using a bicycle ergometer revealed that purine metabolites, i.e. ammonia, ino-sine, hypoxanthine and xanthine, were transiently increased by the exercise and that a subsequent increment in uric acid continued until the following day. The accelerated purine degradation by the muscle exercise was thus shown to be able to cause the overt hyperuricemia in a patient with glycogenosis type V. Therapeutic use of fructose for glycogenosis was disappointing due to fructose-induced hyperuricemia. A search for myogenic hyperuricemia is essential for therapeutic trials.
点击下载:
PDF
(672KB)
返 回