Homopolymerization of acrylamide (AAm) initiated with cyclohexanone (CHn) was carried out in THF at 75°C under argon atmosphere. It was found that the rate of polymerization (Rp) can be expressed by Rp = k[AAm]1.6[CHn]0.6. The polymerization was confirmed to proceed through a radical-initiated mechanism from the resulting polymerization equation. The effects of temperature of the Rp were discussed in the temperature range of 70–80°C. The overall activation energy (Ea) was estimated to be 138.9 kJ/mol. 2,6-Dimethylcyclohexnone (DMCHn) was also applied instead of CHn. The acceleration effect of DMCHn on the polymerization was higher than that of CHn in the case of AAm, but was lower in the case of methyl methacrylate under the same conditions. No effect of CHn on the polymerization ofN,N-dimethylacrylamide was found under these conditions. The participation of -NH2in the complexation of a monomer with CHn is proposed to induce this radical polymerization.