The renin angiotensin system in bypass graft surgery
作者:
Julie Borland,
Adrian Chester,
Magdi Yacoub,
期刊:
Current Opinion in Cardiology
(OVID Available online 2000)
卷期:
Volume 15,
issue 6
页码: 371-377
ISSN:0268-4705
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
The renin angiotensin system is implicated in the development of vein graft disease after coronary artery bypass surgery. Components of this system have been shown to play important roles in determining the short-term and long-term performance of coronary artery bypass grafts. Significant differences exist in the commonly used arterial and venous grafts in angiotensin converting enzyme activity and angiotensin responses. The existence of a dual enzyme pathway in angiotensin II formation has also been demonstrated. Such findings have implications for the use of AT1-receptor antagonists over enzyme inhibitors to improve graft performance and prevent the development of coronary artery bypass graft disease.
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