AbstractThe thickness of the fibrous connective tissue sheath around the corpus cavernosum was measured in a population of 41 men aged 30–90 years. Specimens were obtained from embalmed cadavers and compared with tissue from fresh cadavers. Sections of tissue were stained with hematoxylin and eosin, Masson's trichrome, or VerHoeff‐Van Gieson's to show the connective tissue in the best manner. The thickness was correlated with the presence of inflammation and/ or fibrosis and showed an age‐dependent thinning after the sixth decade of life. The results are related to the age occurrence of Peyronie's disease and the possibility of men with chronic thickening of the tunica albuginea having a predisposition toward developing the di