Characteristics of Biliary Excretion of Cefazolin and Other Cephalosporins with Reference to the Relationship between Serum Levels and Administration Conditions
作者:
Minoru Nishida,
Takeo Murakawa,
Tadao Matsubara,
Yohko Kohno,
Yoshiko Yokota,
Tohru Yasutomi,
Mihoji Okamoto,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 1
页码: 30-36
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221907
出版商: S. Karger AG
关键词: Biliary excretion;Cefazolin;Cephalothin;Cephaloridine
数据来源: Karger
摘要:
The biliary excretion of cefazolin was compared with that of cephalothin and cephaloridine in rats and man. In rats, the biliary levels were dose-related with cefazolin and cephalothin but not with cephaloridine. Biliary levels were higher than serum levels after injection of 10–80 mg/kg of cefazolin and cephalothin, whereas serum levels of cephaloridine after injection were higher than biliary levels. The highest biliary levels of cefazolin were obtained by intravenous injection, followed by intramuscular injection and drip infusion. In man, a crossover study was made to compare biliary levels of cefazolin with those of cephaloridine and cephalothin. After a single 1-gram intravenous injection, the peak levels of cefazolin ranged from 0.85 to 21 μg/ml and those of cephaloridine varied from 0.55 to 3.9 μg/ml. After a 3-gram intravenous injection, the peak biliary levels of cefazolin ranged from 35.5 to 270 μg/ml and those of cephalothin from 0.3 to 64 μg/ml. The chemotherapeutic biliary levels of cefazolin able to inhibit susceptible organisms were obtained by 3-gram intravenous injec
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