Overview of the Clinical Efficacy of Lamotrigine
作者:
A. Richens,
A. W. C. Yuen,
期刊:
Epilepsia
(WILEY Available online 1991)
卷期:
Volume 32,
issue 1
页码: 13-16
ISSN:0013-9580
年代: 1991
DOI:10.1111/j.1528-1157.1991.tb05880.x
出版商: Blackwell Publishing Ltd
关键词: Anticonvulsants;‐Lamotrigine;‐Drug‐induced abnormalities;‐Clinical trials;‐Pharmacokinetics;‐Meta‐analysis
数据来源: WILEY
摘要:
Summary:Testing the efficacy of lamotrigine (LTG) in epileptic patients has been approached in several ways. The first pilot study examined the effect of a single dose of LTG in patients with frequent interictal spikes, and a reduction in spike frequency was observed. Subsequently, single doses reduced photosensitivity in appropriate patients. Single‐blind administration of LTG for 1 week in addition to the patients' regular antiepileptic drugs (AEDs), in patients with refractory seizures, reduced seizures despite the short duration of therapy. This regimen was continued using a placebo‐controlled crossover study with 1‐week duration of treatment. Efficacy in partial and tonic‐clonic seizures was subsequently confirmed in four double‐blind crossover studies; a meta‐analysis of these four studies showed a 30% reduction in partial seizures despite the intractable nature of the seizures in the patients included. Current studies aim at evaluating the drug as monotherapy and in different se
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