Survival and Predictors of Survival in Patients With Congestive Heart Failure Due to Chagas' Cardiomyopathy
作者:
Charles Mady,
Rita Cardoso,
Antonio Barretto,
Protásio da Luz,
Giovanni Bellotti,
Fulvio Pileggi,
期刊:
Circulation
(OVID Available online 1994)
卷期:
Volume 90,
issue 6
页码: 3098-3102
ISSN:0009-7322
年代: 1994
出版商: OVID
关键词: Chagas' disease;cardiomyopathy;ejection fraction;heart failure
数据来源: OVID
摘要:
BackgroundThe fundamental determinant of the natural history of Chagas' disease is cardiac involvement.Methods and ResultsWe studied 104 male patients with congestive heart failure due to Chagas' disease to estimate the survival distribution function and to evaluate age, functional class (FC), maximal oxygen consumption (&OV0622;O2max), and ejection fraction (EF) as predictors of survival. Statistical evaluation was performed through univariate (Student's t test and χ2test) and multivariate analyses (Cox's regression model). Overall survival was 66% at 1 year, 56% at 3 years, and 48% at 5 years. Ages were not statistically different (P= .9811) between survivor (40.3 ± 8.7) and nonsurvivor (40.3 ± 9.4) groups. The ejection fraction(s) were statistically different (P= .0001) between survival (43.6 ± 9.9) and nonsurvival (30.6 ± 8.1) groups, as was &OV0622;O2max (P= .0001) (21.0 ± 4.7 and 15.0 ± 4.9, respectively). Most of the surviving patients were in FC II and most of the nonsurvivors were in FC IV (P= .0001). &OV0622;O2max (P= .0001) and EF (P= .0008) are highly associated with survival time in the multivariate analysis, but FC (P= .0578) is less important. Age (P= .9811) did not influence survival.ConclusionsWe conclude that 50% of the patients with heart failure due to Chagas' disease die in 47 months and that &OV0622;O2max and EF are important indices of survival in this group.
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