Differential expression of vomeromodulin and odorant‐binding protein, putative pheromone and odorant transporters, in the developing rat nasal chemosensory mucosae
作者:
N. S. Rama Krishna,
M. L. Getchell,
F. L. Margolis,
Thomas V. Getchell,
期刊:
Journal of Neuroscience Research
(WILEY Available online 1995)
卷期:
Volume 40,
issue 1
页码: 54-71
ISSN:0360-4012
年代: 1995
DOI:10.1002/jnr.490400107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: vomeronasal organ;olfactory muscosa;respiratory mucosa;lateral nasal glands;vomeronasal glands;septal glands;perireceptor events
数据来源: WILEY
摘要:
AbstractExpression of the putative pheromone and odorant transporter, vomeromodulin, was characterized in developing rat nasal mucosae using in situ hybridization and immunocytochemistry. Initial expression of vomeromodulin mRNA and protein was detected at embryonic day (E)16 in the maxillary sinus component of the lateral nasal glands. The abundance of mRNA and protein in the lateral nasal glands increased with age and reached a peak at postnatal day (P)27. Also at P27, vomeromodulin mRNA and protein expression was initiated in vomeronasal glands and posterior glands of the nasal septum. Comparison of the developmental expression of odorant‐binding protein, another carrier protein synthesized in the lateral nasal glands, with that of vomeromodulin demonstrated major differences. In contrast to vomeromodulin, odorant‐binding protein was not detected until postnatal day 2 in the ventral component of the lateral nasal glands and anterior glands of the nasal septum. These results suggest that the expression of vomeromodulin and odorant‐binding protein is developmentally and differentially regulated and confirms the suggestion that vomeromodulin may function in olfactory and vomeronasal perireceptor processes as a transporter for pheromones and odorants. In addition, the embryonic expression of vomeromodulin suggests its involvement in olfactory perireceptor processes in utero. © 1995 Wiley‐L
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