Magnetically Driven Thrombolytic Preparation Containing Immobilized Streptokinase-Targeted Transport and Action
作者:
V.P. Torchilin,
M.I. Papisov,
N.M. Orekhova,
A.A. Belyaev,
A.D. Petrov,
S.E. Ragimov,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1988)
卷期:
Volume 18,
issue 2
页码: 113-116
ISSN:1424-8832
年代: 1988
DOI:10.1159/000215791
出版商: S. Karger AG
关键词: Drug targeting;Magnetics;Magnetic field;Thrombosis;Streptokinase
数据来源: Karger
摘要:
Streptokinase was immobilized on the magnetic carrier at a concentration of 2,000–2,700 IU/ml of preparation. Thrombosis was induced in both canine carotid arteries by means of the vascular wall flap inverting into its lumen. The red, completely occluding thrombus was formed inside the vessel 4–5 h later. A samarium-cobalt magnet was secured externally to one of the arteries. After the clot formation the magnetically immobilized streptokinase was injected intravenously. The preparation concentrated in the region of the magnetic field action caused complete thrombus degradation and normal blood flow restoration; no effect on the clot in the control artery was obser
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