Effect of inhibition of glucose and fat metabolism on galanin‐R1 receptor mRNA levels in the rat hypothalamic paraventricular and supraoptic nuclei
作者:
O Gorbatyuk,
T Hökfelt,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 16
页码: 3565-3569
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: 2-Deoxy-D-glucose;Galanin-1 receptor;Hypothalamus;Mercaptoacetate;Paraventricular nucleus;Rat;Supraoptic nucleus
数据来源: OVID
摘要:
USINGin situhybridization histochemistry we have studied the effect of glucose and fat deprivation on galanin-R1 receptor (GAL-R1-R) mRNA levels in the rat paraventricular (PVN) and supraoptic (SON) nuclei after single and repeated i.p. administration of a glucose antimetabolite 2-deoxy-D-glucose (DG), as well as of a fatty acid antimetabolite, sodium mercaptoacetate (MA), treatments known to increase food intake. Both DG and MA injections caused an increase in levels of GAL-R1 mRNA transcripts in the PVN and SON. These results indicate that glucose and fat deprivation increase the sensitivity of PVN and SON neurons to galanin, and that regulation of receptor levels may be an important mechanism in galaninergic signalling.
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