A theoretical study of micro-domain formation in mixed lipid membranes
作者:
Antonio Raudino,
期刊:
Liquid Crystals
(Taylor Available online 1988)
卷期:
Volume 3,
issue 8
页码: 1055-1072
ISSN:0267-8292
年代: 1988
DOI:10.1080/02678298808086562
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The thermodynamic stability of micro-clusters in a membrane built-up by charged and uncharged lipid molecules is discussed. A simple variational function is proposed in order to describe the essential structure of such lipid domains. Solvent-screened electrostatic repulsion between the lipid ionic head groups, short-range forces between the lipid hydrophobic taisl and entropic effects are taken into account. The stability conditions as well as the composition and the size of the lipid micro-domains are calculated and expressed as a function of molecular parameters for the membrane and its environment (for example, short-range forces, surface charge density of the lipid bilayer, ion concentration of the electrolyte solution in contact with the lipid membrane and temperature). As an application, the effect of micro-domain formation on the number of adsorbed ions on a charged lipid membrane has been calculated.
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