Leukotriene B4Receptors on Neutrophils in Patients with Psoriasis and Atopic Eczema
作者:
Friedegund Meier,
Eva Gross,
Karl-Norbert Klotz,
Thomas Ruzicka,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1989)
卷期:
Volume 2,
issue 2
页码: 61-67
ISSN:1660-5527
年代: 1989
DOI:10.1159/000210802
出版商: S. Karger AG
关键词: LTB4receptors;Neutrophils;Psoriasis;Atopic eczema
数据来源: Karger
摘要:
Polymorphonuclear leukocyte (PMNL) infiltration is an important characteristic in psoriatic lesions. Elevated concentrations of the chemoattractant eicosanoid leukotriene B4 (LTB4) are present in psoriatic skin. Its chemotactic activity is mediated via high affinity receptors on PMNL. The goal of our work was to ascertain whether PMNL infiltration in psoriasis can be accounted for by functional abnormalities of the circulating PMNL due to alterations in the LTB4 receptor density or affinity (or both). No significant difference was found between patients with psoriasis, healthy controls and patients with another inflammatory dermatosis (atopic eczema) with regard to the binding parameters of LTB4 receptors on PMNL. Our findings suggest that PMNL accumulation in psoriatic skin may be the result of an excess of cutaneous chemoattractant rather than the increased readiness of psoriatic PMNL to migrate towards LTB4 due to altered LTB4 receptor density or affinity.
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