L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan35S Incorporation in Rabbit-Induced Atherogenesis
作者:
Anthony J. Verlangieri,
Jeff W. Stevens,
期刊:
Journal of Vascular Research
(Karger Available online 1979)
卷期:
Volume 16,
issue 4
页码: 177-185
ISSN:1018-1172
年代: 1979
DOI:10.1159/000158205
出版商: S. Karger AG
关键词: L-Ascorbic acid;Cholesterol-induced atherosclerosis;Hyaluronic acid;Heparan sulfate;Chondroitin-4-sulfate;Chondroitin-6-sulfate;Dermatan sulfate;Heparin;35S-incorporation;Aortic cholesterol
数据来源: Karger
摘要:
The effects of L-ascorbic acid on 35S-incorporation into thoracic aorta glycosaminoglycans and upon aorta cholesterol levels were determined in hypercholesterolemic rabbits. No significant difference was observed in serum free or esterified cholesterol levels between animals receiving L-ascorbic acid supplementation or saline while maintained on a cholesterol diet (0.5%). A 15-fold higher serum cholesterol was observed in animals on the cholesterol diet to those animals which received a normal rabbit (Purina) diet. L-Ascorbic acid increased sulfated glycosaminoglycans concentrations in hypercholesterolemic rabbits which paralleled lower tissue free and esterified cholesterol levels. The 35S-specific activity of glycosaminoglycans in hypercholesterolemic animals receiving saline was much greater than in those animals receiving L-ascorbic acid. This suggests that L -ascorbic acid plays a role in the maintenance of adequate levels of aortic sulfated glycosaminoglycans. This then is a suggested biochemical mechanism of L-ascorbic acids interaction in the atherogenic process.
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