Cyclooxygenase-2 Overexpression Correlates With Vascular Endothelial Growth Factor Expression and Tumor Angiogenesis in Gastric Cancer
作者:
Young-Eun,
Joo Jong-Sun,
Rew Young-Ho,
Seo Sung-Kyu,
Choi Young-Jin,
Kim Chang-Soo,
Park Sei-Jong,
期刊:
Journal of Clinical Gastroenterology
(OVID Available online 2003)
卷期:
Volume 37,
issue 1
页码: 28-33
ISSN:0192-0790
年代: 2003
出版商: OVID
关键词: COX-2;VEGF;angiogenesis;gastric cancer;immunohistochemistry
数据来源: OVID
摘要:
Angiogenesis is a key prerequisite for the successful establishment, growth, and dissemination of tumors. Vascular endothelial growth factor (VEGF) has a potent angiogenic activity and cyclooxygenase-2 (COX-2) promotes angiogenesis by modulated production of angiogenic factors including VEGF. The current study was designed to investigate the possible roles of COX-2 and VEGF in gastric cancer angiogenesis. In this study, we conducted an immunohistochemical investigation of COX-2 and VEGF expression in 97 patients with gastric cancer. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD34 immunohistochemical staining. Expression of COX-2 and VEGF in gastric cancer tissues, was demonstrated in 63.9% and 75.3% of cases, respectively. The expression of COX-2 correlated significantly with VEGF expression. High MVD was significantly associated with depth of tumor invasion and poor survival. The mean MVD value of VEGF positive tumors was 79.8 ± 32.0 and significantly higher than that of VEGF negative tumors. The mean MVD value of COX-2 positive tumors was 77.9 ± 29.9 and not significantly higher than that of COX-2 negative tumor. The mean value of MVD in tumors positive for both COX-2 and VEGF was significantly higher than that in tumors negative for both. However, there was no correlation between COX-2 or VEGF expression and various clinicopathological features including patient survival. These results suggest that COX-2 may play an important role in carcinogenesis by stimulating tumor angiogenesis in concert with VEGF in human gastric cancer.
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