SummaryA deep and prolonged coma lasting hours and days may follow a common insulinic hypoglycemia. It does not respond to glucose injection.This non-hypoglycemic coma seems similar to that appearing during the Sakel method after a serie of comas. In that case the coma also can not be reversed by glucose.Among the factors causing this hypersensibility of the nervous system, as they appear in the three cases reported a bad nutritional state and B2 hypovitaminosis play an important part.