Modulation of Parathyroid Cell Function by Calcium Ion in Health and Uremia
作者:
Tadao Akizawa,
Masafumi Fukagawa,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1999)
卷期:
Volume 317,
issue 6
页码: 358-358
ISSN:0002-9629
年代: 1999
出版商: OVID
关键词: Calcium;Parathyroid hormone (PTH);Sigmoidal curve;Calcium-sensing receptor
数据来源: OVID
摘要:
Extracellular calcium ion concentration is the major determinant of parathyroid hormone (PTH) secretion from parathyroid cells. In dialysis patients with secondary hyperparathyroidism, higher calcium concentration is needed to suppress PTH secretion as demonstrated by the PTH-calcium curve. Such abnormal sensitivity to extracellular calcium ion has been recently explained by the decrease in number of calcium-sensing receptors, especially on cells in nodular hyperplasia, which is the advanced type of parathyroid hyperplasia in uremia. Modulation of the sensitivity of parathyroid cells to calcium has become partly possible through the use of newly developed calcimimetics.
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