In situ Hybridization Analysis of Cytomegalovirus and Adenovirus DNA in Immunoglobulin A Nephropathy
作者:
Koji Kanahara,
Yoshihiko Taniguchi,
Noriaki Yorioka,
Michio Yamakido,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 2
页码: 166-168
ISSN:1660-8151
年代: 1992
DOI:10.1159/000187027
出版商: S. Karger AG
关键词: In situ hybridization;Immunoglobulin A nephropathy;Cytomegalovirus;Adenovirus
数据来源: Karger
摘要:
Viruses are thought to play a role in the occurrence of IgA nephropathy. In fact, cytomegalovirus (CMV) antigens have been detected in the glomerular mesangium. To clarify this relationship, we used in situ hybridization with biotin-labeled DNA probes of CMV and adenovirus (AV) in 40 patients with IgA nephropathy to determine the presence or absence of virus in affected renal tissue. Renal tissue DNA from these patients did not hybridize with the CMV or AV probes. Our results fail to support the theory that consecutive regional renal infections with CMV and/or AV are involved in the pathogenesis of IgA nephropathy.
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