Polymyxin B-Induced Cocarde Growth Phenomenon ofSerratia marcescensDue to Cationic Detergent-Like Activity of Polymyxin B
作者:
Walter H. Traub,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 5
页码: 363-368
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238124
出版商: S. Karger AG
关键词: Polymyxin B;Serratia marcescens;Cationic detergents;Cocarde phenomenon
数据来源: Karger
摘要:
14 of 74 test strains of Serratia marcescens yielded reproducible cocarde-like growths (coc+) around 30-μg disks of polymyxin B (PB) on Müller-Hinton, brain heart infusion and tryptic soy agar. The coc+ phenomenon was not due to nutrient effects of growth medium nor did it correlate with either group A (phage tail) bacteriocinogeny or colicinogeny as determined with 32 selected test strains; mitomycin C failed to give rise to coc+ growths. The anionic bile salts of MacConkey agar as well as aqueous sodium deoxy-cholate neutralized the coc+ activity of PB. Benzalkonium chloride, chlorhexidine diglu-conate, and cetyltrimethylammonium bromide by themselves did not produce cocardes. Rather, these cationic detergents enhanced PB activity somewhat against selected coc+ and coc–– strains of 5. marcescens. It was concluded that the PB-induced growth phenomenon of S. marcescens was due to the cationic detergent-like activity of this polypeptide antib
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