Allelic imbalance on chromosome I in human breast cancer. I. Minisatellite and rflp analysis
作者:
Marie‐Louise Loupart,
Susan Adams,
William Brammar,
John Armour,
Rosemary Walker,
Jennifer Varley,
期刊:
Genes, Chromosomes and Cancer
(WILEY Available online 1995)
卷期:
Volume 12,
issue 1
页码: 16-23
ISSN:1045-2257
年代: 1995
DOI:10.1002/gcc.2870120104
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractIn order to characterise the role of chromosome I more fully in breast cancer, polymorphic markers mapping along the length of the whole chromosome were used to assess a panel of 71 tumour‐lymphocyte pairs for allelic imbalance. Complex patterns of alterations were established that are consistent with cytogenetic data in the literature. Deletion mapping of individuals with loss of heterozygosity identified five independent smallest common regions of deletion, two of which are novel. There are also three discrete regions showing a gain in copy number of one homologue. The two arms of the chromosome may be subject to different events; the short arm primarily undergoes interstitial deletions, whereas the long arm is subject to whole arm events (as both gains and losses) as well as regional deletion
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