Assessment of the Wheal Size and Skin Blood Flow of the Erythema Induced by Histamine and Its Modification with Cetirizine and Ebastine: A Crossover, Double-Blind Study
作者:
J. de la Cuadra,
M. Teruel,
P. Teixidó,
J. Roma,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 2
页码: 131-134
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247117
出版商: S. Karger AG
关键词: Histamine;Cetirizine;Ebastine;Laser Doppler
数据来源: Karger
摘要:
In order to assess the antihistaminic power of cetirizine and ebastine, we designed a randomized, double-blind, crossover study, measuring their capacity to modify skin blood flow induced by a histamine prick test. The vasomotor response was compared using a laser Doppler flowmeter. Two hours after intake of the antihistaminic drug, there were significant differences between both drugs: at 4 h, the antihistaminic effect of cetirizine persists, whereas ebastine only showed moderate activity. The reduction of the cutaneous blood flow values (CBFV) showed good activity in both groups, but cetirizine was more potent and showed faster activity than ebastine.
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