Rhabdomyolysis and Acute Renal Failure During High-Dose Haloperidol Therapy
作者:
MarshShawn J.,
DolsonGeorge M.,
期刊:
Renal Failure
(Taylor Available online 1995)
卷期:
Volume 17,
issue 4
页码: 475-478
ISSN:0886-022X
年代: 1995
DOI:10.3109/08860229509037611
出版商: Taylor&Francis
关键词: Acute renal failure;Haloperidol;Neuroleptic malignant syndrome;Rhabdomyolysis
数据来源: Taylor
摘要:
Severe adverse reactions to neuroleptic medications are not uncommon and include the neuroleptic malignant syndrome, rhabdomyolysis, and acute renal failure. The neuroleptic malignant syndrome consists of hyperthermia, diaphoresis, tachycardia, tachypnea, abnormal blood pressure, alteration of consciousness, and extrapyramidal rigidity. Rhabdomyolysis—which might be due to hyperthermia, muscle rigidity, and/or metabolic changes in skeletal muscle function—results in acute renal failure. We report a patient with rhabdomyolysis and acute renal failure that developed after large doses of haloperidol were given, but without muscle rigidity or hyperthermia. This patient's presentation illustrates that high-dose haloperidol therapy might cause rhabdomyolysis and acute renal failure without significant rigidity or hyperthermia.
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