In spite of two hundred years of clinical practice, Homeopathy still lacks of scientific basis. Its fundamental laws, similia principle and the activity of the denominated ultra‐high dilutions are controversial issues that do not fit into the mainstream medicine or current physical‐chemistry field as well. Aside its clinical efficacy, the identification of physical ‐ chemistry parameters, as markers of the homeopathic effect, would allow to construct mathematic models [1], which in turn, could provide clues regarding the involved mechanism. © 2003 American Institute of Physics