Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature
作者:
Makoto Goto,
Kiyoaki Tanimoto,
Yoshihiko Horiuchi,
Takehiko Sasazuki,
期刊:
Clinical Genetics
(WILEY Available online 1981)
卷期:
Volume 19,
issue 1
页码: 8-15
ISSN:0009-9163
年代: 1981
DOI:10.1111/j.1399-0004.1981.tb00660.x
出版商: Blackwell Publishing Ltd
关键词: Aging;autosomal recessive;cancer diathesis;HLA;Werner's syndrome
数据来源: WILEY
摘要:
Forty‐two Japanese families, including 80 individuals with Werner's syndrome were studied, confirming that this syndrome is inherited as an autosomal recessive trait. The incidence of malignancy was relatively high in these families and individuals with Werner's syndrome, although the incidence was not so high as was reported previously. HLA typing revealed no significant linkage with Werner's syndrome. The frequency of Werner's syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million peopl
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