Efficacy of metoclopramide as an adjunct to duodenal placement of small‐bore feeding tubes: a randomized, placebo‐controlled, double‐blind study
作者:
JW Kittinger,
RS Sandler,
WD Heizer,
期刊:
Journal of Parenteral and Enteral Nutrition
(WILEY Available online 1987)
卷期:
Volume 11,
issue 1
页码: 33-37
ISSN:0148-6071
年代: 1987
DOI:10.1177/014860718701100133
出版商: SAGE Publications
数据来源: WILEY
摘要:
We examined whether metoclopramide would improve the success rate of transpyloric intubation of a weighted Corpak feeding tube when fluoroscopic guidance is not used. Seventy patients were randomized in a prospective, double‐blind fashion to receive either placebo (n = 35) or metoclopramide, 10 mg (n = 35) parenterally, administered immediately after the feeding tube was inserted. Tube location was determined independently by two observers who examined radiographs obtained after barium was instilled via the tube. There was no significant increase in the success rate of duodenal intubation in the total group following metoclopramide, 60%, compared to placebo, 49%. However, analysis of subgroups among the placebo‐treated patients revealed that diabetes mellitus, but not other medical conditions, decreased the success rate for duodenal intubation, 20 vs 60% (p less than 0.05). Among diabetic patients, metoclopramide resulted in a significant increase in duodenal placement compared to placebo (p less than 0.05). We conclude that parenteral metoclopramide significantly increases the frequency of transpyloric intubation with small feeding tubes without fluoroscopic guidance in diabetic patients but not in nondiabetic patients.
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