SummaryDue to ihe growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases ofClostridium difficile-associaieddiarrhoea with metronidazole while maintaining the use of oral vancomycin in serious or life-threatening colitis.Clostridium difficileis a common cause of diarThoea after antibiotic therapy and induces a spectrum of diseases ranging from mild diarrhoea to pseudomembranous colitis (PMC). It is considered to be the first cause of diarrhoea occurring among hospitalized patients (1).