Brain myelination in rats treated with ionizing radiation in utero
作者:
M. S. Zaman,
E. W. Hupp,
F. E. Lancaster,
期刊:
Journal of Environmental Science and Health, Part B
(Taylor Available online 1992)
卷期:
Volume 27,
issue 5
页码: 621-638
ISSN:0360-1234
年代: 1992
DOI:10.1080/03601239209372803
出版商: Taylor & Francis Group
关键词: Ionizing radiation;brain myelination;physical development
数据来源: Taylor
摘要:
Effects of ionizing radiation on brain myelination and some physical development parameters were studied in laboratory rats (Fisher F‐344 inbred strain). Rats were treated with three different doses of radiation (150 rad, 15 rad, and 6.8 rad) delivered on the 20th day of prenatal life. Exposure to 150 rad reduced body, brain, ovary, kidney, heart and spleen weights. Prenatal exposure to 150 rad of radiation reduced the cerebral cortex weight by 22 percent at 30 days of age, and 20 percent at 52 days of age which caused a reduction in cerebral cortex myelin content by 20 and 23 percent at the ages of 30 and 52 days respectively. This dose did not affect the myelin content of the cerebellum or the brain stem, or the myelin concentration (mg myelin/g brain tissue) of the cerebral cortex, cerebellum, and the brain stem. The cerebral cortex weight of the 15 rad treated rats was reduced at the age of 30 days. Exposure to 15 rad, and 6.8 rad did not affect either the myelin content or the myelin concentration of these brain areas.
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