The principal electrode problems associated with laser Doppler electrophoresis in high salt conditions and at high current densities (pH drift, colloidal particle ejection, and gas bubbling) have been solved through the use of hybrid electrodes that are platinized Ag/AgCl or by the use of platinized Ag. For salt conditions well below physiological saline an agarose gel overcoating on either of these electrode types has been useful for containing the increased tendency for the ejection of colloidal particles.