Long‐term effects of status epilepticus induced by kainic acid on hippocampal polyamines
作者:
Lidia Giménez-Llort,
Emili Martínez,
Lluïsa Camón,
Núria de Vera,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 5
页码: 937-941
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Epilepsy;Hippocampus;Kainic acid;Polyamines;Rats
数据来源: OVID
摘要:
PUTRESCINE has been suggested to have an inhibitory effect on the excitability of the central nervous system. In the present study we found that 2 and 3 weeks after status epilepticus induced by kainic acid, rats had increased concentrations of putrescine (3- and 1.7-fold, respectively) and spermidine (1.6- and 1.4-fold, respectively) in the hippocampus. These animals exhibited a higher susceptibility to pentylentetrazol than the saline group. In addition, several hours after the pentylentetrazol injection, the concentration of putrescine and spermidine increased again in the brain and also in the plasma. In conclusion, increased hippocampal putrescine and spermidine concentrations seem to be linked with a lower threshold of excitability.
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