Urinary GH Secretion Correlates with Plasma GH Levels during Sleep and GHRH Stimulation Tests but Not during theL-Dopa Stimulation Test in Prepubertal Children
作者:
D. Porguet,
A. Fjellestad-Paulsen,
J. Leger,
D. Simon,
P. Czernichow,
D. Evain-Brion,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1993)
卷期:
Volume 39,
issue 1-2
页码: 19-24
ISSN:1663-2818
年代: 1993
DOI:10.1159/000182689
出版商: S. Karger AG
关键词: Growth hormone;Urine;GHRH test;L-Dopa test;Children
数据来源: Karger
摘要:
In order to assess the value of urinary growth hormone (GH) as a reflection of central GH release, 42 prepubertal children with short stature and without organic disease were studied. A nocturnal GH profile and L-dopa and GH-releasing hormone (GHRH) tests were performed. Urinary GH was measured by means of a direct immunoradiometric method we have developed, using two monoclonal antibodies. Nocturnal urinary GH values correlated positively with plasma GH values expressed as the area under the curve (r = 0.76; p = 0.0001) or mean peak amplitude (r = 0.73; p = 0.0001). Also, urinary GH values correlated positively with peak plasma GH levels during the GHRH test (r = 0.64; p = 0.001). In contrast, no correlation was observed between peak plasma GH and urinary GH during the L-dopa test (r = 0.29; p = 0.11). This suggests a specific but as yet undetermined effect of L-dopa on urinary GH secretion.
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