Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease
作者:
Anne Eckert,
Carl Cotman,
Rainer Zerfass,
Michael Hennerici,
Walter Müller,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2443-2446
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alzheimer's disease;Apoptosis;Lymphocytes;Nucleosomes
数据来源: OVID
摘要:
ALL important neuropathological features like neurodegeneration and amyloid deposition occur similarly in familial and in sporadic Alzheimer's disease (AD) patients, suggesting a common pathogenetic mechanism. We investigated whether defective vulnerabilty to the induction of the apoptotic cell death pathway might be one of the underlying mechanisms leading to progressive cell death in sporadic AD. Our test could prove useful in supporting the diagnosis of AD and in predicting individuals predisposed to AD.
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