The effect of chronic propranolol therapy on regional cerebral blood flow in hypertensive patients.
作者:
Globus M,
Keren A,
Eldad M,
Granot C,
Tzivoni D,
Lavy S,
Stern S,
期刊:
Stroke
(OVID Available online 1983)
卷期:
Volume 14,
issue 6
页码: 964-967
ISSN:0039-2499
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
In 31 hypertensive patients the effect of chronic oral administration of the beta blocking agent propranolol on regional cerebral blood flow (rCBF) was studied, using the non-invasive 133Xenon inhalation technique. The results of the measurements were compared to the rCBF obtained in an age-matched normal control group. Our study shows that during long-term therapy with low doses of propranolol (less than 120 mg/daily) the rCBF is unaffected, but it is increased significantly if higher doses (greater than 120 mg/daily) are used. In all six patients who served as their own control, as they had basic rCBF measurements before or during low-dose propranolol, the rCBF on high-dose propranolol became significantly increased. The possible mechanisms which may cause the increased rCBF on high-dose propranolol are discussed.
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