24‐HOUR RAT LIVER PRESERVATION USING UW SOLUTION AND SOME SIMPLIFIED VARIANTS
作者:
RYO SUMIMOTO,
NEVILLE JAMIESON,
KENJIRO WAKE,
NAOSHI KAMADA,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 1
页码: 1-5
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
The results of a series of 32 rat liver transplants are described to analyze the efficacy of components of UW solution. Rat livers were stored at 4°C in standard UW solution or one of three simplified variants for 24 hr prior to orthopic liver transplantation. In standard UW solution (solution A) the one-week survival rate was 3 of 8. Using solution B, which differs from solution A in the omission of hydroxyethyl starch and adenosine, the one-week survival rate was 2 of 8. Solution C, a further-simplified version of solution B with omission of allopurinol, Bactrim, and insulin, gave a one-week survival rate of 3 of 8. Solution D is identical to solution B except that the sodium and potassium concentrations are reversed. Using this solution, 5 of 8 rats survived more than one week.We conclude that the effectiveness of UW solution is maintained in a substantially simplified form, and that solution D, with the Na/K ratio reversed to give a high Na variant, may improve survival.
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